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KMID : 0861020080230010117
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Korea Journal of Herbology
2008 Volume.23 No. 1 p.117 ~ p.125
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Study on the Attributive Channel Theory of Herbal Medicine by the Pharmacodynamic Research of I-131 Labelled Hesperetin
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Kim Sung-Kyu
Ham In-Hye
Bu Young-Min
Kim Ho-Cheol
Cho Jung-Hyuck
Choi Ho-Young
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Abstract
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Objectives: This study was to verify the Attributive Channel theory of herbal medicine.
Methods: [131I]iodohesperetin was synthesized, separated, and refined from hesperetin, the major
component of Citrus species, followed by observing the biodistribution in an organism of C57 BL/6 mice
with and without Lewis Lung Carcinoma.
Results: Iodohesperetin 27.5 mg was obtained through column chromatography after a reaction with 50
mg of Hesperitin and 8 mg of NaI. The radiochemical yield of [131I]iodohesperetin synthesis was 25 %
when checked with Radio TLC chromatography. [131I]iodohesperetin was most largely distributed in the
stomach, lung and liver of C57BL/6 mouse. The highest %ID/g in stomach was 40 min, in lung and liver
was 20 min after injection. The % ID/g of tumor tissue was comparable with that of blood.
Conclusions: The fact that [131I]iodocurcumin was most largely distributed in the stomach, lung and
liver was related with the Attributive Channel theory. And there was no significant finding related to
tumor cells
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KEYWORD
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Attributive Channel, I-131, Hesperetin, biodistribution
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